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. 2015 May 27;2:15019. doi: 10.1038/mtm.2015.19

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Cytocochleograms showing percentage of missing IHCs and OHCs assessed in deafened ears that were injected with Ad.HSP70-mCherry versus the contralateral control ears (with no further manipulation) (a) and Ad.mCherry (control viral vector) versus the contralateral control ears (b). (a) In both Ad.mCherry-injected and contralateral ears, kanamycin/furosemide eliminated nearly all IHC and OHCs in the basal half of the cochlea. In the apical two turns, the elimination of IHC and OHCs is incomplete. (b) IHC survival is substantially enhanced in the Ad.HSP70-mCherry-injected ears compared to both controls (a). Ad.HSP70-mCherry did not reduce the loss of OHCs because of kanamycin/furosemide. The number of mCherry animals =7. The number of HSP70-mCherry animals =12. IHC, inner hair cell; HSP, heat shock protein, OHC, outer hair cell.