Fig. 9.

Conservation of the positively charged residues in the cytochrome c sequences. Sequence logos were generated with WebLogo [89] from multiple alignments of bacterial and eukaryotic cytochrome c sequences from fully sequenced genomes. The numeration of residues corresponds to the mature human cytochrome c. Each position in the logo corresponds to a position in the alignment while the size of letters in the position represents the relative frequency of corresponding amino acid in this position. Red arrows indicate residues experimentally proven to be involved in interaction with Apaf-1