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. 2013 Oct 23;1(1):17. doi: 10.1186/2049-9256-1-17

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© Nauczyciel et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic of the limbic corticostriatal loop (from a schematic by Cardinal, 2006 showing key structures involved in reward process and anhedonia and loss of motivation observed in MDD. DA: dopamine, Glut: glutamate, NA: noradrenalin, VTA: ventral tegmental area. The Nac seems to be at the centre of this circuitry: between the emotional system (amygdala, basal ganglia, insula, medial prefrontal cortex, orbitofrontal cortex, VTA), the cognitive system (anterior cingulate cortex) and motor control system (hippocampus).