Nigral delivery of lentiviral vectors; rotational behavior. (a) Apomorphine induced rotations at 2, 4, 6, and 8 weeks after lesion; (b) Amphetamine induced rotations at 8 weeks after lesion. Newman–Keuls post hoc test, *P < 0.05; **P < 0.01, n ≥ 6 per group. Immuno-fluorescence on 40 µm coronal sections at 8 weeks following unilateral preterminal lesion with 6-OHDA. Lentiviral transduction in the substantia nigra following intranigral delivery of (c) Lenti.CDNF-GFP or (d) Lenti.MANF-GFP. Sections were stained for CDNF or MANF (Red), GFP (Green) and DNA (Blue). Scale bars = 100 µm.