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. 2014 Dec 2;23(2):244–254. doi: 10.1038/mt.2014.206

Figure 6.

Figure 6

Nigral delivery, TH immunohistochemistry. (a) Striatal TH-fiber density at 8 weeks after viral transduction using TH immunohistochemistry on coronal sections of the corpus striatum (Bregma +0.6), representative sections of Lenti.GFP, Lenti.CDNF-GFP, Lenti.MANF-GFP, and Lenti.GDNF-GFP. (b) Intranigral delivery of CDNF but not MANF or GDNF can prevent the loss of striatal TH innervation caused by 6-OHDA compared to GFP-control animals. (c) Immunohistochemistry of TH on coronal sections of the substantia nigra; (d) Intranigral delivery of CDNF fails to protect nigral dopamine neurons against 6-OHDA toxicity but both MANF and GDNF are protective compared to GFP-control animals. Newman–Keuls post hoc test *P < 0.05; **P < 0.01; ***P < 0.001, n ≥ 6 per group.