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. 2015 May 20;5:10035. doi: 10.1038/srep10035

Figure 1. Extended Renin Angiotensin Aldosterone System (ExtRAAS).

Figure 1

The metabolic cascades of angiotensin peptides, and cortico-and gluco-corticoid pathways have been represented using symbols of genes coding for the substrate, the enzymes and the receptors involved in the pathway. Angiotensin peptides and steroid hormones are represented in grey using their usual abbreviation. Ang, Angiotensin; Preg, Pregnanolone; Prog, Progesterone; DOC, deoxycortisol; 17-OHP, 17-OH Progesterone; ACE, angiotensin I converting enzyme; ACE2, angiotensin I converting enzyme type 2; AGTR1, angiotensin II type 1 receptor; AGTR2, angiotensin II type 2 receptor; AKRIC4, aldo-keto reductase family 1, member C4; AKRID1, aldo-keto reductase family 1, member D1; ANPEP, alanyl-aminopeptidase; ATP6AP2, prorenin/renin receptor; CMA1, chymase 1; CPA3, carboxypeptidase A3; CTSA, cathepsin A; CTSD, cathepsin D; CTSG, cathepsin G; CYP11A1, cytochrome P450, family 11, subfamily A, polypeptide 1; CYP11B1, cortisol synthase; CYP11B2, aldosterone synthase; CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1; CYP21A2, cytochrome P450 enzyme, family 21, subfamily A, polypeptide 2; DPP3, dipeptidyl-peptidase 3; ENPEP, glutamyl aminopeptidase (aminopeptidase A); GR, glucocorticoid receptor; HSD11B1, hydroxysteroid (11-beta) dehydrogenase 1; HSD11B2, hydroxysteroid (11-beta) dehydrogenase 2; IGF2R , insulin-like growth factor 2 receptor; KLK1, tissue kallikrein; LNPEP, leucyl/cystinylaminopeptidase; MAS1, MAS1 proto-oncogene; MME, membrane metallo-endopeptidase; MR, mineralocorticoid receptor; NLN, neurolysin (metallopeptidase M3 family); PREP, prolylendopeptidase; REN, renin; RNPEP, arginyl aminopeptidase (aminopeptidase B); THOP1, thimetoligopeptidase 1. Images of IGF2R36, ATP6AP237, MR38, GR39, G-protein coupled receptors (AGTR1, AGTR2, GPER and MAS1)40 and LNPEP41 were obtained from the Protein Data Bank in Europe (PDBe) with respective PDBe IDs: 2YDO, 3LBS, 1P93, 4P8Q, 2AA2. Image of EGFR42 was obtained from Protein Data Bank DOI:10.2210/rcsb_pdb/mom_2010_6.