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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: J Endocrinol. 2012 Jun 22;214(3):437–443. doi: 10.1530/JOE-12-0145

Figure 4.

Figure 4

A model depicting PPP1R12A/PP1cδ in the insulin signaling pathway. Insulin stimulation leads to the activation of PI3K, PDK1, Akt, and mTOR/Raptor, as well as PPP1R12A. This leads to increased interaction between IRS-1 and PPP1R12A/PP1cδ and the ability of the PPP1R12A/PP1cδ complex to dephosphorylate IRS-1. The main purpose of activation of the PPP1R12A/PP1cδ complex to dephosphorylate IRS1 may be to counterbalance the effect of insulin-activated serine/threonine kinases, resulting in balanced IRS1 pS/pT and proper insulin action through IRS1.