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. 2015 Feb 3;5(2):e501. doi: 10.1038/tp.2014.138

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Copyright © 2015 Macmillan Publishers Limited

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Neuroligins show sex-dependent expression. Hippocampal RNA from 5-to 6-month-old mice was analyzed by quantitative real-time PCR (n=6–8 mice per group). The 4 NGLN genes were compared. (a) NGLN1: two-way analysis of variance (ANOVA) showed a significant effect of sex (F(1,26)=16.754, P<0.001), but no significant effect of genotype (P=0.561). Fisher's LSD post hoc test revealed a significant difference between male mice compared with female mice for both ADNP^+/+ and ADNP^+/− (^*P<0.05). (b) NGLN2: two-way ANOVA showed no significant effect of sex (P=0.777) and no significant effect of genotype (P=0.450). (c) NGLN3: two-way ANOVA showed a significant effect of sex (F(1,24)=7.800, P=0.010), but no significant effect of genotype (P=0.771). Fisher's LSD post hoc test revealed a significant difference between ADNP^+/− male mice compared with ADNP^+/− female mice (*P<0.05). (d) NGLN4: two-way ANOVA showed a significant effect of sex (F(1,25)=12.258, P=0.002), but no significant effect of genotype (P=0.482). Fisher's LSD post hoc test revealed a significant difference between ADNP^+/− male mice compared with ADNP^+/− female mice (*P<0.05). (e) Nine-month-old male mice, NGLN1: no specific genotype effect, like (a) 5- to 6-month old. (f) Nine-month-old male mice, NGLN2. (g) Nine-month-old male mice, NGLN3. (h) Nine-month-old male mice, NGLN4. ADNP, activity-dependent neuroprotective protein; LSD, least significant difference.