Table 2. Normalized weighted miRNA list.
miRNA name | Normalized weight responders | Normalized weight non-responders | Normalized difference | (z-score) | Enriched pathways | −log(P-value) |
---|---|---|---|---|---|---|
hsa-miR-551a | 0.0017 | 0.00141 | 0.000282 | 3.08 | CXCR4 signaling Semaphorin signaling in neurons Agrin interactions at the neuromuscular junction | 2.03E+00 2.01E+00 1.80E+00 |
hsa-miR-551b-3p | 0.0017 | 0.00141 | 0.000282 | 3.08 | Agrin interactions at the neuromuscular junction ErbB signaling Renin–angiotensin signaling | 2.83E+00 2.62E+00 2.42E+00 |
hsa-miR-326 | 0.00457 | 0.00434 | 0.000231 | 2.25 | α-Adrenergic signaling IL-1 signaling Gαs signaling | 2.70E+00 2.62E+00 2.41E+00 |
hsa-miR-330-5p | 0.00457 | 0.00434 | 0.000231 | 2.25 | Role of Oct4 in mammalian embryonic stem cell pluripotency p70S6K signaling AMPK signaling | 2.92E+00 2.10E+00 2.00E+00 |
hsa-miR-216b | 0.00358 | 0.00381 | 0.000229 | 2.21 | Extrinsic prothrombin activation pathway Coagulation system Semaphorin signaling in neurons | 2.92E+00 2.25E+00 1.91E+00 |
hsa-miR-1 | 0.00355 | 0.00377 | 0.000222 | 2.09 | Flavin biosynthesis IV (mammalian) Role of IL-17F in allergic inflammatory airway diseases TREM1 signaling | 2.25E+00 2.23E+00 1.79E+00 |
hsa-miR-206 | 0.00355 | 0.00377 | 0.000222 | 2.09 | Gαi signaling Serotonin receptor signaling G-protein-coupled receptor signaling | 2.17E+00 2.07E+00 2.04E+00 |
hsa-miR-613 | 0.00355 | 0.00377 | 0.000222 | 2.09 | Xenobiotic metabolism signaling Hepatic cholestasis CDK5 signaling | 2.79E+00 2.72E+00 2.37E+00 |
hsa-miR-15a-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides | 1.53E+00 1.20E+00 1.04E+00 |
hsa-miR-15b-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides | 1.53E+00 1.20E+00 1.04E+00 |
hsa-miR-16-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides | 1.53E+00 1.20E+00 1.04E+00 |
hsa-miR-195-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides | 1.53E+00 1.20E+00 1.04E+00 |
hsa-miR-424-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | L-carnitine biosynthesis Sucrose degradation V (mammalian) Calcium transport I | 2.48E+00 2.06E+00 2.01E+00 |
hsa-miR-497-5p | 0.00435 | 0.00413 | 0.00022 | 2.07 | Phospholipase C signaling Complement system Inhibition of matrix metalloproteases | 1.63E+00 1.49E+00 1.41E+00 |
hsa-miR-384 | 0.00388 | 0.0041 | 0.000218 | 2.03 | Lysine degradation II Leukocyte extravasation signaling Pathogenesis of multiple sclerosis | 1.80E+00 1.63E+00 1.55E+00 |
hsa-miR-448 | 0.00325 | 0.00346 | 0.000215 | 1.98 | nNOS signaling in neurons Glutathione biosynthesis Ephrin A signaling | 2.06E+00 2.04E+00 2.03E+00 |
Abbreviation: miRNA, microRNA.
Shown is a normalized weighted list of miRNAs for the responder and non-responder groups along with computed z-scores.