Table 2. Normalized weighted miRNA list.

miRNA name	Normalized weight responders	Normalized weight non-responders	Normalized difference	(z-score)	Enriched pathways	−log(P-value)
hsa-miR-551a	0.0017	0.00141	0.000282	3.08	CXCR4 signaling Semaphorin signaling in neurons Agrin interactions at the neuromuscular junction	2.03E+00 2.01E+00 1.80E+00
hsa-miR-551b-3p	0.0017	0.00141	0.000282	3.08	Agrin interactions at the neuromuscular junction ErbB signaling Renin–angiotensin signaling	2.83E+00 2.62E+00 2.42E+00
hsa-miR-326	0.00457	0.00434	0.000231	2.25	α-Adrenergic signaling IL-1 signaling Gαs signaling	2.70E+00 2.62E+00 2.41E+00
hsa-miR-330-5p	0.00457	0.00434	0.000231	2.25	Role of Oct4 in mammalian embryonic stem cell pluripotency p70S6K signaling AMPK signaling	2.92E+00 2.10E+00 2.00E+00
hsa-miR-216b	0.00358	0.00381	0.000229	2.21	Extrinsic prothrombin activation pathway Coagulation system Semaphorin signaling in neurons	2.92E+00 2.25E+00 1.91E+00
hsa-miR-1	0.00355	0.00377	0.000222	2.09	Flavin biosynthesis IV (mammalian) Role of IL-17F in allergic inflammatory airway diseases TREM1 signaling	2.25E+00 2.23E+00 1.79E+00
hsa-miR-206	0.00355	0.00377	0.000222	2.09	Gαi signaling Serotonin receptor signaling G-protein-coupled receptor signaling	2.17E+00 2.07E+00 2.04E+00
hsa-miR-613	0.00355	0.00377	0.000222	2.09	Xenobiotic metabolism signaling Hepatic cholestasis CDK5 signaling	2.79E+00 2.72E+00 2.37E+00
hsa-miR-15a-5p	0.00435	0.00413	0.00022	2.07	Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides	1.53E+00 1.20E+00 1.04E+00
hsa-miR-15b-5p	0.00435	0.00413	0.00022	2.07	Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides	1.53E+00 1.20E+00 1.04E+00
hsa-miR-16-5p	0.00435	0.00413	0.00022	2.07	Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides	1.53E+00 1.20E+00 1.04E+00
hsa-miR-195-5p	0.00435	0.00413	0.00022	2.07	Sonic hedgehog signaling Pyridoxal 5'-phosphate salvage pathway Salvage pathways of pyrimidine ribonucleotides	1.53E+00 1.20E+00 1.04E+00
hsa-miR-424-5p	0.00435	0.00413	0.00022	2.07	L-carnitine biosynthesis Sucrose degradation V (mammalian) Calcium transport I	2.48E+00 2.06E+00 2.01E+00
hsa-miR-497-5p	0.00435	0.00413	0.00022	2.07	Phospholipase C signaling Complement system Inhibition of matrix metalloproteases	1.63E+00 1.49E+00 1.41E+00
hsa-miR-384	0.00388	0.0041	0.000218	2.03	Lysine degradation II Leukocyte extravasation signaling Pathogenesis of multiple sclerosis	1.80E+00 1.63E+00 1.55E+00
hsa-miR-448	0.00325	0.00346	0.000215	1.98	nNOS signaling in neurons Glutathione biosynthesis Ephrin A signaling	2.06E+00 2.04E+00 2.03E+00

Abbreviation: miRNA, microRNA.

Shown is a normalized weighted list of miRNAs for the responder and non-responder groups along with computed z-scores.