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. 2015 Feb 17;5(2):e512. doi: 10.1038/tp.2015.2

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Cortico–hippocampal connectivity in Ddo^−/− mice. Transverse and coronal brain section heat maps showing voxels for which the fMRI BOLD signal was significantly correlated with the ventral hippocampus (seed regions in black) in (a) Ddo^+/+and (b) Ddo^−/− mice. The z-score indicates the strength of the correlation. (c) A stronger and more widespread profile of cortical (somatosensory) hippocampal connectivity was apparent in Ddo^−/− mice. Strength (r-score) of cortico–hippocampal connectivity in representative regions of interest of Ddo^+/+ and Ddo^−/− mice. **P<0.01, Student's t-test. Cg, cingulate cortex; DDO, D-aspartate oxidase; fMRI, functional magnetic resonance imaging; PFC, prefrontal cortex; S1, somatosensory (parietal) cortex; vHc, ventral hippocampus; V1, visual cortex.