. 2015 Feb 24;5(2):e513. doi: 10.1038/tp.2015.6

Table 2. Predictive formula of Hamilton Rating Scale for Depression (HAM-D) % change at week 6.

PAX; (n=81, R²=0.25, P<0.001)=41.6%+33.9% × A

FLV; (n=42, R²=0.43, P<0.001)=39.3%+19.8% × A+16.3% × B +16.4% × E

MIL; (n=45, R²=0.71, P<0.001)=−28.1%+54.4% × A+52.8% × C +14.2% × D

Alphabets in regression equation and frequency of favorable genotype and EPI

A; EPI Yes, (Pax, 70% Flv, 50% Mil, 60%)

B; 5-HTTLPR L_A (26.8%), C; HTR1A-1019G/G (4.2%)

D; ADRA2A C (51.8%), E; FGF2 T (26.2%)

Abbreviations: EPI, early partial improvement; FLV, fluvoxamine; MIL, milnacipran; PAX, paroxetine.

When the patient has the genotype above, corresponding alphabet in the regression equation is 1. When the patient does not have such a genotype, corresponding alphabet in equation is 0.