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. 2015 May 16;12:43. doi: 10.1186/s12977-015-0168-2

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© Konstantoulas et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Virus replicating in human cells carries a human APOBEC3G signature of cytosine deamination. Nucleotide sequences obtained as described in Figure 3 were examined for the presence of hAPOBEC3G-mediated nucleotide changes on minus sense DNA. (A) All possible nucleotide transversions and transitions detected in the pro (a portion), pol, env and sag genes are expressed as a percentage of total number of nucleotide substitutions. (B) All C-to-T mutations found in the minus sense DNA strand were analysed for sequence context at the −1 and −2 nucleotide position.