Table 3.
Gene mutations and clinical characteristics
| wt vs | mut | P value | |
|---|---|---|---|
| TET2 | |||
| Age(>65y), % | 36.2 | 61.2 | 0.005 |
| BM blasts(>10 %), % | 37.8 | 17 | 0.008 |
| WBC(109/L), median, range | 12.96(3.05–98.03) | 16.00(3.01–70.50) | 0.961 |
| ANC(109/L), median, range | 5.83(0.30–66.91) | 8.78(1.12–28.64) | 0.617 |
| AMC(109/L), median, range | 3.06(1.02–18.00) | 3.13(1.06–17.63) | 0.874 |
| Hb(g/L), median, range | 91.0(43.0–158.0) | 88.0(43.0–166.0) | 0.409 |
| PLT(109/L), median, range | 68.0(3.8–895.0) | 87.0(9.0–1001.0) | 0.866 |
| SRSF2 | |||
| Age(>65y), % | 24.2 | 64.1 | 0.000 |
| BM blasts(>10 %), % | 33 | 26.2 | 0.361 |
| WBC(109/L), median, range | 11.47(3.01–98.03) | 21.35(5.06–70.50) | 0.007 |
| ANC(109/L), median, range | 4.92(0.30–66.91) | 13.55(1.75–33.90) | 0.008 |
| AMC(109/L), median, range | 2.29(1.02–18.00) | 3.72(1.16–17.63) | 0.004 |
| Hb(g/L), median, range | 84.0(43.0–166.0) | 106.5(56.0–166.0) | 0.000 |
| PLT(109/L), median, range | 67.5(3.8–895.0) | 100.0(9.0–1001.0) | 0.392 |
| ASXL1 | |||
| Age(>65y), % | 52.3 | 53.8 | 0.863 |
| BM blasts(>10 %), % | 28.8 | 38.8 | 0.393 |
| WBC(109/L), median, range | 11.47(3.01–92.40) | 20.10(3.62–98.03)) | 0.123 |
| ANC(109/L), median, range | 5.17(0.30–66.91) | 10.45(0.46–56.66) | 0.052 |
| AMC(109/L), median, range | 2.52(1.06–18.00) | 3.20(1.02–14.82) | 0.082 |
| Hb(g/L), median, range | 92.0(44.0–166.0) | 87.5(43.0–158.0) | 0.187 |
| PLT(109/L), median, range | 69.0(6.6–1001.0) | 90.5(3.8–633.0) | 0.487 |
| SETBP1 | |||
| Age(>65y), % | 57.7 | 52.1 | 0.605 |
| BM blasts(>10 %), % | 29.4 | 38.5 | 0.415 |
| WBC (109/L), median, range | 12.69(3.01–98.03) | 20.46(6.60–49.10) | 0.173 |
| ANC (109/L), median, range | 5.50(0.30–66.91) | 11.75(2.56–33.90) | 0.079 |
| AMC (109/L), median, range | 2.62(1.06–18.00) | 3.25(1.02–11.03) | 0.413 |
| Hb(g/L), median, range | 88.5(43.0–166.0) | 90.5(52.0–137.0) | 0.622 |
| PLT(109/L), median, range | 74.25(5.0–1001.0) | 118.5(3.8–534.0) | 0.337 |