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. 2015 May 27;15:431. doi: 10.1186/s12885-015-1440-5

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© Pelkonen et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Cox regression multivariate analysis of breast cancer survival. Patients were divided into high and low expression groups relative to the median expression values (a, b). Cox regression analysis of survival according to the expression of (a), TMPRSS1 mRNA (median follow-up time 9.79 years); b, TMPRSS3 mRNA (median follow-up time 9.51 years); c, TMPRSS1 and TMPRSS3 mRNA (median follow-up time 9.79 years); and d, hepsin and TMPRSS3 protein expression (median follow-up time 11.05 years). In addition to expression levels, tumor grade, nodal status, tumor size, hormone receptor status, and histologic type were included in the multivariate analyses. Positive nodal status and large tumor size (T3, T4) were other parameters that were significantly associated with poorer breast cancer survival in the multivariate analyses