Table 3.
Iron content of differential EGFR-expressing cells after a 2-hour incubation at 37°C with the synthesized iron oxide nanoparticles
| Cell line | Treatment | Mean iron concentration (μg Fe/4×106 cells) | SD | Fold |
|---|---|---|---|---|
| 32D | Cell only | 0.330 | 0.0033 | 1.00 |
| PEG-dexSPIONs | 0.667 | 0.0093 | 2.02 | |
| Cet-PEG-dexSPIONs | 0.772 | 0.0092 | 2.34 | |
| 32D/EGFR | Cell only | 0.335 | 0.0039 | 1.00 |
| PEG-dexSPIONs | 0.798 | 0.0081 | 2.38 | |
| Cet-PEG-dexSPIONs | 2.771 | 0.0111 | 8.27 | |
| A431 | Cell only | 0.344 | 0.0057 | 1.00 |
| PEG-dexSPIONs | 0.549 | 0.0022 | 1.60 | |
| Cet-PEG-dexSPIONs | 6.401 | 0.0937 | 18.61 |
Abbreviations: cet, cetuximab; dex, dextran; EGFR, epidermal growth factor receptor; PEG, polyethylene glycol; SD, standard deviation; SPIONs, superparamagnetic iron oxide nanoparticles.