Table 6.
Effects on hematology, liver function, and kidney function parameters in healthy BALB/c mice determined by acute toxicity study (n=20)
| Parameter | Tan IIA-NPs | Drug-free NPs | Saline | |
|---|---|---|---|---|
| Hematology | WBCs (G/L) | 5.04±0.62 | 4.96±0.85 | 5.10±0.92 |
| RBCs (T/L) | 8.27±0.97 | 8.04±0.75 | 8.01±0.89 | |
| PLTs (G/L) | 989.6±98.42 | 1,025.7±131.77 | 1,037.2±140.54 | |
| Lymphocytes (%) | 65.7±2.74 | 66.1±3.02 | 66.4±3.85 | |
| Liver function | AST (U/L) | 103±4.80 | 110±6.24 | 107±3.94 |
| ALT (U/L) | 47.2±5.71 | 46.9±7.41 | 45.1±4.80 | |
| TBIL (μmol/L) | 1.02±0.045 | 1.09±0.072 | 1.07±0.078 | |
| Kidney function | BUN (mmol/L) | 4.07±0.96 | 4.12±0.75 | 4.23±0.69 |
| CR (μmol/L) | 8.3±1.01 | 8.2±0.88 | 8.3±0.85 | |
| UA (μmol/L) | 16.7±3.31 | 16.4±2.96 | 16.0±3.75 | |
| HCO3 (mmol/L) | 2.43±0.47 | 2.39±0.88 | 2.46±0.65 |
Notes: Data are presented as mean ± standard deviation. There was no significant difference of the above parameters compared with the saline group (P>0.05).
Abbreviations: AST, aspartate aminotransferase; ALT, alanine transaminase; BUN, blood urea nitrogen; CR, creatinine; NPs, nanoparticles; PLTs, platelets; RBCs, red blood cells; Tan IIA-NPs, tanshinone IIA liquid NPs; TBIL, total bilirubin; UA, uric acid; WBCs, white blood cells.