Table 1.

Population estimates of the proposed PK/PD model using Monolix.

Parameters	Estimate	RSE (%)a
kG (min−1)	0.24	21
Emax (min−1)	0.0185	16
C50 (mg/dl)	73.8	6
Pe (L−1)	0.0581	25
ke (min−1)	0.194	12
kRR (min−1)	0.499	0.2
α	4.05	13
IR0 (µU)	4530	34
CI_0 (µU/ml)	8.7	12
kR·IR (µU/min)‡	1580b	31
β_kRIR	−0.922	27
b	0.185	3
Standard deviation of parameters
kG	0.296
Emax	0.189
C50	0.224
Pe	0.146
ke	0.505
kRR	0.216
α	0.278
IR0	0.403
CI_0	0.659
kR·IR (African-American)	0.608
kR·IR (Caucasian)	0.699

^aRSE, relative standard error.

^bThe value is for African-American which is used as reference.

k_R·I_R of Caucasian is calculated as: 1580 × exp(−0.922) = 628.

^‡p = 0.00016.