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. 2015 May 16;15:411. doi: 10.1186/s12885-015-1405-8

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© Pedraz-Cuesta et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of glutamate transporter inhibition on cellular GSH levels. a Basal intracellular GSH levels were measured as described in Materials and Methods, and normalized to total protein in the samples. b-c Normalized basal GSH levels under control conditions, in HCT116 and LoVo parental and resistant cells after 24 h of treatment with 0.8 μM SN38 or 20 μM oxaliplatin, in absence or presence of DL-TBOA (350 μM) as shown. * p < 0.05 vs untreated control group (n = 5). One-way ANOVA followed by Dunnett post-test