Table 3. Plasma Concentrations of compounds of protein glycation and oxidation.
Analyte | Women with normal fasting glucose | Women with impaired fasting glucose | p* | p** |
---|---|---|---|---|
Precursor molecule | ||||
FruLys [mM] | 3.5 (3.2; 3.8) | 3.7 (3.2; 4.0) | 0.3866 | 0.2982 |
Free metabolites | ||||
3-DF [μM] | 2.7 (2.4; 3.7) | 2.4 (1.9; 2.9) | 0.1836 | 0.3058 |
3-DPs [nM] | 18.8 (16.0; 21.1) | 17.6 (13.5; 20.3) | 0.0846 | 0.1283 |
3-DP [nM] | 705.1 (389.9; 832.3) | 720.3 (424.3; 912.9) | 0.4756 | 0.5446 |
Hydroimidazolones | ||||
MGH1 [nmol/mmol Arg] | 178.0 (104.2; 222.6) | 200.8 (162.1; 259.3) | 0.0763 | 0.0765 |
3-DGH [nmol/mmol Arg] | 74.8 (28.5; 108.9) | 62.5 (28.5; 104.8) | 0.9544 | 0.9012 |
Oxidated adducts | ||||
CML [nM] | 676.6 (554.1; 804.5) | 688.0 (599.1; 809.7) | 0.4400 | 0.4505 |
CEL [nM] | 152.8 (137.1; 173.4) | 169.0 (135.9; 131.3) | 0.1409 | 0.1669 |
MetSO [mM] | 2.1 (1.7; 3.2) | 2.5 (1.7; 2.9) | 0.8267 | 0.9188 |
Data are given as median with 25th and 75th percentiles;
* unadjusted p value;
** p value adjusted for age, BMI, smoking status, passive smoking and education.
3-DF, 3-deoxyfructose; 3-DPs, 3-deoxypentosone; 3-DP, 3-deoxypentulose; MGH1, methylglyoxal-derived hydroimidazolone 1; 3-DGH, 3-deoxyglucosone-derived hydroimidazolone; CML, carboxymethyl lysine; CEL, carboxyethyl lysine; MetSO, methionine sulfoxide; FruLys, Nε-fructosyllysine.