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Simplified diagram of 6MP and MTX interaction
*Circumstantial evidence indicates that these metabolites are associated with myelotoxicity and hepatotoxicity, respectively. Ery-6TGN, erythrocyte levels of 6-thioguanine nucleotides; FPGS, folyl-polyglutamyl synthetase; HPRT, hypoxanthine-guanine phosphoribosyltransferase; MTX, methotrexate; MTXpg, methotrexate polyglutamates; TPMT, thiopurine methyltransferase; XO, xanthine oxidase; 6MP, 6-mercaptopurine.
