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. 2015 Apr 15;6(1):73. doi: 10.1186/s13287-015-0050-0

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© Kol et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Multiple allogeneic mesenchymal stem cell (MSC) injections do not induce anaphylaxis or alter leukocyte concentration. (A) There were no significant changes in temperature, heart rate, or respiration rate throughout the course of MSC administration. (B) White blood cell count (WBC) did not change throughout the course of the study. Neutrophil (C) and lymphocyte (D) counts did not change throughout the course of the study. These data demonstrate that multiple high-dose injections of allogeneic MSCs do not result in an anaphylactic response and do not elicit a change in leukocyte concentration. Data are presented as mean ± standard error of the mean. Grey boxes demonstrate the 95% confidence interval (CI) of the day 0 and control samples. AT, adipose tissue; BM, bone marrow; D, day.