Table 4.
Functionally important candidate genes upregulated in VMN
| Category | Blast2GO description |
|---|---|
| Neurotransmission | Anoctamin-5-like isoform x4 |
| ATP-sensitive inward rectifier potassium channel 8-like | |
| Calcium-activated potassium channel subunit alpha-1-like (kcnma1) isoform 3 | |
| Gamma-aminobutyric acid receptor subunit alpha-3-like (gabra3) | |
| Gamma-aminobutyric acid receptor subunit alpha-5-like (gabra5) | |
| Gamma-aminobutyric acid receptor subunit pi-like (gabrp) | |
| Gamma-aminobutyric acid type b receptor subunit 1-like | |
| Gap junction beta-6 (cx30) | |
| Glutamate ionotropic kainate 3-like | |
| Glutamate ionotropic kainate 5-like | |
| Glutamate receptor delta-1 subunit-like | |
| Glycine receptor subunit beta | |
| Glycine receptor subunit beta-like | |
| Kv channel-interacting protein 4-like | |
| Muscarinic acetylcholine receptor m2 (chrm2) | |
| Neuronal acetylcholine receptor subunit alpha-2-like (chrna2) | |
| Neuronal acetylcholine receptor subunit alpha-3-like | |
| Neuronal acetylcholine receptor subunit alpha-9-ii-like | |
| Neuronal acetylcholine receptor subunit beta-2-like | |
| Neuronal acetylcholine receptor subunit non-alpha-3-like (chrnb3) | |
| Potassium sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like | |
| Potassium voltage-gated channel subfamily b member 2 (kcnb2/Kv2.2) | |
| Potassium voltage-gated channel subfamily c member 3-like (kcnc3/Kv3.3) isoform x1 | |
| Potassium voltage-gated channel subfamily e member 1-like | |
| Potassium voltage-gated channel subfamily h member 5 | |
| Potassium voltage-gated channel subfamily kqt member 2-like (kcnq2/Kv7.2) | |
| Potassium voltage-gated channel subfamily s member 1-like (kcns1/Kv9.1) | |
| Potassium voltage-gated channel subfamily s member 3-like | |
| Sodium channel protein type 5 subunit alpha | |
| Sodium channel subunit beta-4-like | |
| Transient receptor potential cation channel subfamily m member 2-like | |
| Two pore calcium channel protein 1-like | |
| Voltage-dependent l-type calcium channel subunit alpha-1f-like | |
| Voltage-dependent r-type calcium channel subunit alpha-1e | |
| Voltage-gated potassium channel subunit beta-1 isoform 1 (kcnab1) | |
| Voltage-gated potassium channel subunit beta-2-like isoform 1 | |
| Steroid pathway | 3-keto-steroid reductase-like (hsd17b7) |
| Androgen receptor alpha (ar-a) | |
| Androgen-induced gene 1 protein | |
| Dihydroxyvitamin d 24- mitochondrial-like isoform 1 | |
| Estrogen receptor beta 2 (esr2) | |
| Estrogen-related receptor alpha | |
| Hydroxysteroid 11-beta-dehydrogenase 1-like (hsd11b1l) | |
| Lanosterol 14-alpha demethylase-like | |
| Ovarian aromatase (cyp19a1a) | |
| Sterol regulatory element-binding protein 1 | |
| Sterol regulatory element-binding protein 2 | |
| Neuropeptides/peptide hormones | Atrial natriuretic peptide-converting enzyme-like |
| Calcitonin gene-related peptide precursor | |
| Cholecystokinin type a receptor | |
| Growth hormone receptor | |
| Inhibin beta b chain-like | |
| Insulin gene enhancer protein isl-1 | |
| Insulin-like growth factor binding protein 1 | |
| Insulin-like growth factor i | |
| Neuropeptide b precursor | |
| Peptide yy-like | |
| Pituitary adenylate cyclase-activating polypeptide type i receptor-like | |
| Vasoactive intestinal polypeptide receptor 1-like | |
| Thyroid hormone | Thyroid hormone receptor alpha |
| Thyroid hormone receptor-associated protein 3-like | |
| Thyroid receptor-interacting protein 6-like | |
| Other neuromodulators | Adenosine receptor a1-like |
| D-like dopamine receptor-like (drd2) | |
| Melatonin receptor type 1a-like | |
| Prostaglandin e synthase 2-like | |
| Prostaglandin f2-alpha receptor-like | |
| Antioxidants | Cu/Zn superoxide dismutase (sod1) |
| Glutaredoxin 3 | |
| Glutaredoxin-related protein 5 | |
| Glutathione peroxidase 4b (gpx4b) | |
| Glutathione s-transferase (gst) | |
| Peroxiredoxin 6 | |
| Thioredoxin domain-containing protein 17 | |
| Thioredoxin-dependent peroxide mitochondrial precursor | |
| Thioredoxin-like protein 1 | |
| Thioredoxin-like protein 4a |
Gene descriptions with neurotransmission, neuroendocrine, and antioxidant functions from transcripts upregulated in VMN compared to surrounding hindbrain. Genes that are mentioned in the text or shown in figures have gene symbols in parentheses.