Table 1.
Summary of mutations included in the curated whole genome drug resistance library
| Drug | Loci | No. variable sites | SNPs | Indels |
|---|---|---|---|---|
| INH | katG | 241 | 286 | 25 |
| katG promoter | 3 | 3 | 0 | |
| inhA | 12 | 15 | 0 | |
| inhA promoter | 9 | 11 | 0 | |
| ahpC | 8 | 8 | 0 | |
| ahpC promoter | 13 | 14 | 0 | |
| kasA | 8 | 11 | 0 | |
| RMP | rpoB | 89 | 135 | 19 |
| rpoC | 8 | 8 | 0 | |
| EMB | embB | 123 | 153 | 1 |
| embA | 5 | 5 | 0 | |
| embA promoter | 3 | 3 | 0 | |
| embC | 25 | 26 | 0 | |
| embR | 22 | 24 | 0 | |
| STR | rrs | 21 | 25 | 0 |
| rpsL | 14 | 19 | 0 | |
| PZA | pncA | 215 | 269 | 64 |
| pncA promoter | 4 | 6 | 0 | |
| rpsA | 3 | 4 | 0 | |
| panD | 9 | 11 | 1 | |
| ETH | ethA | 33 | 29 | 5 |
| ethR | 3 | 4 | 0 | |
| inhA promoter | 3 | 3 | 0 | |
| inhA | 3 | 3 | 0 | |
| FLQs | gyrA | 15 | 22 | 0 |
| gyrB | 22 | 29 | 0 | |
| AMK | rrs | 8 | 9 | 0 |
| CAP | rrs | 3 | 4 | 0 |
| tlyA | 26 | 18 | 10 | |
| KAN | rrs | 3 | 4 | 0 |
| eis promoter | 9 | 10 | 0 | |
| PAS | thyA | 23 | 17 | 5 |
| folC | 16 | 19 | 0 | |
| ribB | 1 | 1 | 0 | |
| LZD | rrl | 2 | 2 | 0 |
| rplC | 1 | 1 | 0 | |
| BDQ CFZ | Rv0678 | 7 | 5 | 2 |
AMK, amikacin; BDQ, bedaquiline; CAP, capreomycin; CFZ, clofazimine; EMB, ethabutol; ETH, ethionamide; FLQs, fluoroquinolones; INH, isoniazid; KAN, kanamycin; LZD, linezolid; PAS, para-aminosalycylic acid; PZ, pyrazinamide; RMP, rifampicin; STR, streptomycin.