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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neurogastroenterol Motil. 2015 Apr 5;27(6):865–874. doi: 10.1111/nmo.12561

Figure 1. Mild acid stimulates esophageal DRG C-fibers by a mechanism independent of TRPV1.

Figure 1

(A) Examples of electrophysiological traces of baseline activity and the response to modest acid (pH=6.0). (B) pH-dependency of the activation of esophageal DRG C-fibers by acid. (C) The response to mild acid (pH=6) was not inhibited by pretreatment with the TRPV1 receptor selective antagonist I-RTX (1μM) although I-RTX nearly abolished the response to capsaicin in the same experiment (vehicle n=7, I-RTX n=5). *P<0.05.