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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Neurol. 2015 Apr 27;269:224–232. doi: 10.1016/j.expneurol.2015.04.013

Figure 1. 97Q and myogenic transgenic (Tg) males show comparable disease-related deficits in BDNF transcripts in skeletal muscle.

Figure 1

Both slow twitch soleus and fast twitch extensor digitorum longus (EDL) muscles of motor-impaired mice show significant deficits in all three BDNF transcripts (noncoding IV and VI and the coding IX) based on qPCR (A, B). Since the disease-causing AR is expressed only in muscle fibers of myogenic mice, these data indicate that AR can act directly in muscle fibers to down-regulate BDNF mRNA (A), possibly triggering dysfunction not only in skeletal muscles, but in the motoneurons too. All plotted values are relative to Wt controls (dashed line). Error bars represent standard error of the mean. n=6-7/group. * p<0.01 from Wt control