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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Neurol. 2015 Apr 27;269:224–232. doi: 10.1016/j.expneurol.2015.04.013

Figure 2. Presymptomatic castration rescues 97Q males from deficits in both muscle BDNF mRNA and motor function.

Figure 2

Deficits in muscle BDNF mRNA and motor function of gonadally-intact, end-stage 97Q Tg males are not evident in 97Q males castrated at puberty. Both BDNF expression and motor function of castrated Tg males is comparable to Wt males. Note that we find the same deficits in BDNF mRNA in gonadally-intact 97Q males as in the first experiment (Fig. 1A) and that castration of Wt males has no effect on BDNF mRNA (A), nor motor function. Error bars represent standard error of the mean. n=6/group. A) * p<0.01 from Wt+Sham, † p<0.05 from Tg+Sham. B) # p<0.05 Tg+Castrate versus Tg+Sham.