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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Neurol. 2015 Apr 27;269:224–232. doi: 10.1016/j.expneurol.2015.04.013

Figure 3. Castration reverses deficits in both muscle BDNF mRNA expression and motor function of chronically diseased myogenic males.

Figure 3

Deficits in muscle BDNF (A) and motor function (B) found in gonadally intact Tg males are largely reversed by castration, indicating that both defects are androgen-dependent. Note that we find comparable BDNF deficits in gonadally-intact Tg males as seen in first experiment (Fig 1B) and that castration of Wt males affects neither BDNF expression nor motor function based on hang times and grip strength but does lower rearing behavior, an androgen-dependent measure of anxiety. That castration did not reverse the rearing deficit in Tg males may reflect increased anxiety-like behavior and not an effect on motor function per se. Error bars represent standard error of the mean. n=4-5/group. A) * p<0.01 from Wt+Sham, † p<0.05 from Tg+Sham. B) # p<0.05 Tg+Castrate versus Tg+Sham.