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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Neurol. 2015 Apr 27;269:224–232. doi: 10.1016/j.expneurol.2015.04.013

Figure 5. Androgen induces the deficit in muscle BDNF mRNA before detectable motor dysfunction in acutely diseased myogenic females.

Figure 5

Muscle BDNF mRNA was significantly reduced after only one day of testosterone (T) treatment (A). Importantly, this deficit preceded the loss in overt motor function; deficits in hang time were evident starting at three days of T treatment but not before. The magnitude of the deficit at 24 hours was not only comparable to that at 5 days of T treatment in Tg females but also comparable to that of chronically affected myogenic and 97Q Tg males (Fig. 1), suggesting that a defect in BDNF mRNA expression in muscle is an early event in disease progression and might trigger the loss in overt motor function. Error bars represent standard error of the mean. n=4-6/group. A) * indicates p<0.05 from Wt Day 0. B) # p<0.05 Wt versus Tg.