Table 1.
Baseline characteristics of CORRONA subjects with rheumatoid arthritis
| Total cohort (n = 24,989) |
Clinical Disease Activity Index at baseline |
||||
|---|---|---|---|---|---|
| Remission (n = 5,511) |
Low (n = 8,411) |
Moderate (n = 6,638) |
High (n = 4,429) |
||
|
|
|||||
| Percentages unless otherwise noted | |||||
| Female gender | 77 | 72.6 | 75.2 | 78.7 | 79.2 |
| Age, mean (± SD) (years) | 58.9 (±13.4) | 58.1 (±13.8) | 59.5 (±13.5) | 59.2 (±13.2) | 58.3 (±13.0) |
| Age, <45 years | 14 | 16.6 | 14.0 | 13.0 | 14.0 |
| 45-64 years | 51 | 50.0 | 49.3 | 52.3 | 54.8 |
| 65+ years | 35 | 33.5 | 36.8 | 34.7 | 31.3 |
| Race, White | 89 | 90.4 | 89.4 | 88.0 | 87.2 |
| Black | 7 | 6.0 | 6.6 | 7.9 | 7.5 |
| Other | 4 | 3.6 | 4.0 | 4.1 | 5.4 |
| College education | 55 | 61.7 | 57.0 | 50.9 | 47.4 |
| Tobacco use, None | 66 | 68.2 | 67.5 | 65.0 | 62.5 |
| Previously | 15 | 12.1 | 13.5 | 16.3 | 18.7 |
| Currently | 19 | 19.6 | 19.0 | 18.7 | 18.9 |
| BMI, mean (±SD) (kg/m2) | 29.2 (±7.1) | 28.1 (±6.3) | 29.9 (±6.88) | 29.8 (±7.42) | 30.3 (±7.7) |
| Alcohol use (Y/N) | 43 | 51.4 | 44.6 | 39.0 | 36.0 |
| Alcohol use, None | 57 | 48.7 | 55.4 | 61.2 | 64.1 |
| Rarely | 21 | 23.7 | 21.5 | 20.3 | 18.4 |
| 1-3 drinks weekly | 17 | 21.6 | 18.2 | 14.4 | 14.0 |
| 7+ weekly | 21 | 6.0 | 4.9 | 4.2 | 3.5 |
| Cardiovascular risk factors | |||||
| Prior MI | 3 | 2.4 | 3.2 | 3.3 | 3.6 |
| Presence of CAD | 17 | 16.3 | 16.5 | 17.0 | 17.8 |
| Diabetes | 8 | 5.9 | 7.1 | 8.0 | 9.7 |
| Hypertension | 29 | 25.8 | 29.9 | 31.4 | 29.2 |
| Hyperlipidemia | 25 | 23.7 | 25.5 | 24.5 | 25.2 |
| Family history of MI | 3 | 2.6 | 2.8 | 2.8 | 3.2 |
| Physical activity*, none | 32 | 25.1 | 30.4 | 35.1 | 39.2 |
| 1-2 | 30 | 30.5 | 31.2 | 29.7 | 29.8 |
| 3-4 | 21 | 26.2 | 22.1 | 19.1 | 15.8 |
| 5-6 | 6 | 8.5 | 6.5 | 5.4 | 3.7 |
| 7 + | 10 | 9.7 | 9.8 | 10.7 | 11.5 |
| Aspirin use, yes/no | 29 | 25.3 | 27.8 | 28.0 | 27.9 |
| RA characteristics | |||||
| Duration of RA (years) | 10.1 (±9.8) | 8.7 (±8.6) | 10.3 (±9.8) | 10.8 (±10.4) | 10.4 (±10.1) |
| Seropositive# | 77 | 75.3 | 77.9 | 78.6 | 76.5 |
| CDAI | 12.3 (±11.9) | 1.2 (±0.8) | 6.1 (±2.1) | 15.3 (±3.4) | 33.0 (±10.9) |
| Modified HAQ | 0.4 (±0.5) | 0.1 (±0.2) | 0.3 (±0.4) | 0.5 (±0.5) | 0.7 (±0.6) |
| DAS-28 | 3.4 (±1.6) | 1.8 (±0.8) | 2.8 (±0.8) | 4.0 (±0.9) | 5.6 (±1.1) |
| Baseline medication use | |||||
| Prednisone, no use | 66 | 78.8 | 67.4 | 59.4 | 57.7 |
| 1-4 mg | 10 | 9.0 | 11.5 | 10.9 | 8.6 |
| 5-9 mg | 14 | 7.5 | 13.3 | 17.6 | 17.8 |
| 10+ mg | 6 | 2.4 | 4.8 | 7.8 | 11.3 |
| NSAID or coxib | 61 | 55.1 | 61.6 | 63.6 | 62.7 |
| Methotrexate | 84 | 82.5 | 85.0 | 84.8 | 85.1 |
| TNF antagonist | 49 | 42.8 | 46.8 | 51.3 | 54.7 |
| Rituximab | 3 | 1.1 | 1.8 | 3.2 | 4.8 |
| Abatacept | 4 | 2.2 | 3.4 | 4.9 | 6.7 |
| Tocilizumab | 0.4 | 0.1 | 0.2 | 0.5 | 0.7 |
Physical activity in number of exercise sessions per week. # Seropositive is based on rheumatoid factor or anti-CCP.
Abbreviations: RA, rheumatoid arthritis; CDAI, clinical disease activity index; HAQ, modified health assessment questionnaire; DAS, disease activity score-28; MI, myocardial infarction; CAD, coronary artery disease; BMI, body mass index
Missing data by variable: gender, n = 98; age, n = 157; education, n = 1,301; tobacco use, n = 6,838; BMI, n = 393; alcohol use, n = 1,002; duration of RA, n = 153; seropositive, n = 9,877; modified HAQ, n = 457; DAS28, n = 14,278; prednisone use, n = 870; physical activity, n = 1,405; and aspirin use, n = 434. Percentages are calculated based on the total number of subjects, including those with missing values.