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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Obesity (Silver Spring). 2015 May 9;23(6):1209–1217. doi: 10.1002/oby.21086

Figure 6. RSV decreases leukocyte adhesion in obese septic mice via SIRT-1 modulation.

Figure 6

RSV treated ob/ob mice with sepsis were treated with SIRT-1 specific inhibitor EX-527 and leukocyte and platelet adhesion were studied in small intestinal microcirculation using IVM and compared to Sepsis + Vehicle (black bars) and Sepsis + RSV (dark grey) treated groups. Leukocyte (Figure 6A) and platelet adhesion (Figure 6B) in Sepsis + RSV + EX-527 (light grey) groups were significantly increased compared to Sepsis + RSV group. There was no statistically significant difference in leukocyte and platelet adhesion between Sepsis + Vehicle vs. Sepsis +RSV + EX-527 group. # p<0.05 vs. Sepsis + Vehicle; ≠ p<0.05 vs. Sepsis + RSV. We next studied the E-selectin and ICAM-1 expression using immunohistochemistry (20× magnification) in Sepsis + Vehicle, Sepsis + RSV and Sepsis + RSV + EX-527 treated ob/ob mice with sepsis. As shown in Figure 6C and D, E-selectin and ICAM-1 expression in Sepsis + RSV + EX-527 treated mice were increased compared to Sepsis + RSV respectively.