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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Pediatr. 2015 Feb 13;166(6):1351–1357.e1. doi: 10.1016/j.jpeds.2015.01.017

Figure 1. Etiology of normocytic anemia due to chronic inflammation.

Figure 1

Chronic inflammation results in the development of normocytic anemia via a combination of 1) decreased erythropoietin (EPO) production in the kidney, 2) hepcidin-mediated decreased iron availability from macrophages and the duodenal enterocytes, and 3) decreased bone marrow responsiveness to EPO.