Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SHAPE chemistry monitors local nucleotide dynamics and non-canonical interactions. (A) Mechanism of RNA SHAPE chemistry to form 2'-O-adducts at flexible nucleotides. (B) Core set of useful SHAPE reagents. (C) Structural contexts for nucleotides exhibiting NMIA (green) and 1M6 (blue) enhancements superimposed on a model for the TPP riboswitch aptamer domain; the bound ligand shown in gray. Structure illustrations for the TPP riboswitch are based on 2gdi.30
