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RING-MaP overview. (A) Detection of through-space structural communication. RNA molecules experience local structural variations in which nucleotides become reactive to a chemical probe in a correlated way. Statistical association analysis detects these interdependencies. (B) Analysis of multiple coexisting RNA conformations based on clustering analysis. Initial RING-MaP experiments were performed with the RNA-modifying reagent dimethyl sulfate (DMS).28
