Table 6. Global DNA methylation in mothers of children with DS depending on the MTHFR C677T genotype/diet.
Mothers of children with DS: N = 90 | N (%) | Global DNA methylation (%)* |
---|---|---|
MTHFR C677T genotype/diet | ||
CC/folate rich diet | 21 (23) | 96.42 [90.70–99.73] |
CT+TT/folate rich diet | 16 (18) | 94.72 [90.56–99.90] |
CC/folate poor diet | 22 (25) | 95.09 [91.36–98.95] |
CT+TT/folate poor diet | 31 (34) | 94.30 [79.13–99.48] |
*Median [min—max]
P = 0.383