Table 2.
Summary of fMRI data for experimental contrasts of interest in participant groups.
| Group | Contrast | Region | Side | Cluster (voxels) |
Peak (mm) |
t-Value | p-Value | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Healthy controls | Sound versus silence | HG | L | 4344 | −44 | −21 | 4 | 12.10 | <0.001 |
| Mid STG | R | 4635 | 60 | −12 | −2 | 11.56 | <0.001 | ||
| Name identificationa | Mid STG/STS | L | 1788 | −56 | −13 | −2 | 10.31 | <0.001 | |
| R | 1989 | 66 | −16 | −5 | 11.38 | <0.001 | |||
| Post STG | L | 219 | −62 | −24 | 1 | 8.22 | 0.001 | ||
| R | 35 | 65 | −18 | 6 | 5.46 | 0.039 | |||
| Segregation processingb | PT/ SMG | R | 172 | 65 | −36 | 19 | 5.68 | 0.028 | |
| AD patients | Sound versus silence | Mid STG | L | 3639 | −56 | −21 | 3 | 23.14 | <0.001 |
| Post STG | R | 3990 | 54 | −22 | 10 | 11.79 | <0.001 | ||
| Name identification | Ant STG/STS | L | 652 | −59 | 0 | −15 | 8.34 | 0.003 | |
| R | 1073 | 62 | −1 | −6 | 8.34 | 0.003 | |||
| Segregation processing | Post STG/PT | R | 67 | 65 | −37 | 24 | 6.48 | 0.047 | |
| Cocktail party effectc | SMG | R | 39 | 55 | −22 | 28 | 6.47 | 0.048 | |
| Patients > controls | Cocktail party effect | SMG | R | 57 | 55 | −21 | 28 | 6.06 | 0.002 |
Statistical parametric data summarising regional brain activations for contrasts between experimental conditions of interest, in each participant group and between groups. All contrasts shown are thresholded at p < 0.05FWE after multiple comparisons correction in pre-specified anatomical small volumes.
NS own natural name superimposed on babble, RI spectrally rotated name interleaved with babble, RS spectrally rotated name superimposed on babble; no significant activations were identified for the ‘forward’ segregation contrast [(NS + RS) − (NI + RI)] in either participant group, for the cocktail party contrast in the healthy control group or for auditory stimulation, name identification or segregation processing between groups. AD, Alzheimer's disease; Ant, anterior; HG, Heschl's gyrus; Post, posterior; PT, planum temporale; SMG, supramarginal gyrus; STG, superior temporal gyrus; STS, superior temporal sulcus.
Contrast [(NS + NI) − (RS + RI)].
Contrast [(NI + RI) − (NS + RS)].
Contrast [(NI − RI) − (NS − RS)] where NI is own natural name interleaved with babble, NS own natural name superimposed on babble, RI spectrally rotated name interleaved with babble, RS spectrally rotated name superimposed on babble.