Figure 2.

Effect of silica nanoparticle (SiNP) on mouse platelet aggregation in vitro. Platelets were incubated at 37°C with SiNP for 3 min, stirred for another 3 min, and then single platelets were counted. Platelet aggregation was quantified by measuring the fall in single platelets counted due to aggregation induced by SiNP or saline. The degree of platelet aggregation following SiNP or saline (control) exposure was expressed as ℅ of that obtained in untreated platelets. Data are mean ± SEM (n = 5). Statistical analysis by one-way ANOVA followed by Dunnett’s multiple range tests.