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The RNF168/53BP1 pathway is altered in a subset of BRCA1-deficient tumors. Mutation data for two TCGA studies were extracted from cBioPortal (www.cbioportal.org) and used to generate oncoprints showing examples of RNF168/53BP1 pathway heterogeneity in BRCA1-deficient tumors (39–58). Asterisks denote tumors where BRCA1 is mutated in one allele and deleted in the other. All other BRCA1-mutated tumors contain heterozygous germline mutations.
