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. 2015 Apr 20;43(10):4833–4854. doi: 10.1093/nar/gkv370

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — RAR/RXR targeted region coincide with pluripotency- and differentiation-associated transcription factors binding sites. (A) Correlation between RAR/RXR and the indicated factors binding sites. Data sets used for the correlation study were obtained in mouse ES cells (open bars) or mouse F9 EC cells (blue bars). (B) Distance distribution of the orphan nuclear receptors ESRRB (upper panel) and NR5A2 (lower panel) binding regions identified in mouse ES cells that overlap with RAR/RXR binding regions identified in F9 EC cells relative to RAR/RXR region center. (C) Distance distribution of the pluripotency-associated transcription factors binding regions identified in mouse ES cells that overlap with RAR/RXR binding regions identified in F9 EC cells relative to RAR/RXR region center. (D) Distance distribution of POU5F1 and SOX17 binding regions that overlap with RAR/RXR binding regions identified in F9 EC cells relative to RAR/RXR region center. The number between brackets represents the absolute number of RAR/RXR binding regions (peak summit ± 250 bp, blue area) that overlap with the indicated transcription factor.