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The effects of CRF are blocked by the CRFR1 antagonist antalarmin. In (A) we show a representative image of the control recording (on the left). The image on the right shows that in presence of 10 μM antalarmin CRF was without effect on the activation of the PC circuitry. In (B) we show dose inhibition curve for CRFR1 receptor blockade in Layer II of PC over the range of antalarmin concentrations used. The IC50 for antalarmin was found to be 100 nM.
