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. 2015 May 28;9:72. doi: 10.3389/fnana.2015.00072

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Copyright © 2015 Vera, Recabal, Saldivia, Stanic, Torrejón, Montecinos and Caprile.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioinformatics analyses of LDLrA domains present in the SCO-spondin sequence of Gallus gallus. (A) Multiple alignment of SCO-spondin LDLrA domains and comparison with the LDLrA domain sequence of the human LDL receptor (LDLRh). (B) Multiple alignment of the SCO-spondin LDLrA5 domain from different species. For all species analyzed this domain conserved the DxSDE motif, or a conservative substitution of serine to threonine (in red). (C) Hydropathic plot of the SCO-spondin sequence that contains the LDLrA domains, showing its hydrophilic character, especially for the regions containing the DxSDE motifs. (D) Tertiary structure of the SCO-spondin region that contains the LDLrA domains arranged in tandem. Each domain is shown in a different color; DxSDE motifs are highlighted in green, and disulfide bridges are in white.