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(A) Mitochondrial membrane permeabilization effects of 5c.a (B) Diagram showing the distribution cells with permeabilized mitochondrial membrane among all tested compounds
a Experiments were performed in triplicate (N =3).Control sample presented an average of 14% permeabilized cells whereas the Camptothecin positive control 48.5% and Curcumin analog 23.0%. Compound 5c presented 68% of cells with permeabilized mitochondrial membrane which is statistically significant (P<0.05).
