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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Mar 31;25(10):2174–2180. doi: 10.1016/j.bmcl.2015.03.065

Table 1.

1H-NMR and 13C-NMR characterization of C5-Curc-FA conjugates.a,b,c

Compound graphic file with name nihms676734t1.jpg
13C-NMR chemical shift (ppm) 1H-NMR chemical
shift (ppm),
multiplicity 		H2–H3
coupling
constant (Hz)
C1 C2 C3 C4 H2 H3
5a 190.0 121.8 148.3 168.6 6.45, d 7.60, d 15.8
5b 191.9 122.2 147.6 170.8 6.56, d 7.53, d 16.1
5c 190.8 122.0 147.2 167.0 6.67, d 7.56, d 16.2
5d 190.3 122.6 148.0 173.0 6.45, d 7.60, d 15.8
5e 190.0 122.3 147.9 168.9 6.44, d 7.60, d 15.8
5f 192.1 120.9 141.1 172.9 6.52, d 7.48, d 15.8
5g 188.9 121.1 147.1 171.6 6.48, d 7.37, d 16.3
6a 190.0 137.4 139.7 168.9 None 7.53, s None
6b 192.6 136.4 139.8 174.4 None 7.62, s None
6c 190.7 136.9 139.5 173.4 None 7.52, s None
a

Signals from FA moieties were observed at 0.85–2.44 ppm in 1H-NMR and 13.1–34.0 ppm in 13C-NMR. Signals from cyclohexanone moieties were observed at 1.62–2.28 ppm and 2.95–3.33 ppm in 1H-NMR and 22.1–23.8 ppm and 25.6–29.4 ppm in 13C-NMR.

b

Signals from methoxy groups in compounds 5a, 5b, 5e, 5f, 6a, and 6b were observed at 3.78–3.83 ppm in 1H-NMR and 54.1–56.0 ppm in 13C-NMR.

c

Signals from aromatic groups were observed at 6.59–7.80 ppm in 1H-NMR and 107.2–157.3 ppm in 13C-NMR.