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. 2015 Apr 30;13(5):2732–2756. doi: 10.3390/md13052732

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

PPARγ and LXRα mRNA in adipose tissue. PPARγ and LXRα function as obligate heterodimers with retinoid X receptors (RXR) and influence gene transcription via multiple mechanisms. In keeping with their functions as lipid sensors, ligand-bound PPAR or LXR activate feed-forward metabolic cascades that regulate lipid homeostasis via the transcription of genes involved in lipid metabolism, storage, and transport. PPARγ activates a battery of genes involved in lipid storage and lipogenesis, allowing adipose tissue safely to store greater quantities of fat and undergo differentiation.