| Cross-reactive - non allergic (Non-immunologically mediated reactions) |
NSAIDs exacerbated respiratory disease |
NERD |
Reaction manifesting primarily as bronchial obstruction, dyspnea and nasal congestion/rhinorrhea, occurring in patients with an underlying chronic airway respiratory disease (asthma/rhinosinusitis/nasal polyps). |
aspirin triad, asthma triad, Samter's syndrome, Widal syndrome, aspirin-induced asthma or aspirin-sensitive rhinosinusits/asthma syndrome, aspirin-intolerant asthma, aspirin-exacerbated respiratory disease
|
| NSAIDs exacerbated cutaneous disease |
NECD |
Reaction manifesting as wheals and/or angioedema occurring in patients with a history of chronic spontaneous urticaria. |
aspirin-induced urticaria; aspirin-exacerbated cutaneous disease
|
| NSAIDs induced urticaria-angioedema |
NIUA |
Reaction manifesting as wheals and/or angioedema occurring in otherwise healthy subjects (without history of chronic spontaneous urticaria). Symptoms are induced by at least two NSAIDs with different chemical structure (not belonging to the same chemical group). |
aspirin-induced urticaria; multiple drug-induced urticarial angioedema
|
| Selective-allergic (Immunologically mediated reactions) |
Single NSAID-induced urticaria/angioedema or anaphylaxis |
SNIUAAA |
Immediate hypersensitivity reactions to a single NSAID or to several NSAIDs belonging to the same chemical group, manifesting as urticaria, angioedema and/or anaphylaxis. These subjects tolerate other chemically non-related NSAIDs, and usually do not have a history of chronic urticaria or asthma. |
single drug-induced reactions, allergic reactions
|
| NSAIDs-induced delayed hypersensitivity reactions |
NIDHR |
Reactions to a single NSAID developing more than 24 hours after drug administration and manifesting by either skin symptoms (exanthema, fixed drug eruption), other organ specific symptoms (e. g. renal, pulmonary) or severe cutaneous adverse reactions (SCAR). |
