Abstract
The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mirabilis as infecting organisms. Cinoxacin was considerably more effective than either nalidixic acid or oxolinic acid when all three were administered orally at 3 mg/kg four times daily. The presence of demonstrable serum activity with a high recovery in urine indicates cinoxacin possesses highly desirable properties of an effective oral chemotherapeutic agent for urinary tract infections.
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Selected References
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- BEESON P. B., GUZE L. B. Experimental pyelonephritis. I. Effect of ureteral ligation on the course of bacterial infection in the kidney of the rat. J Exp Med. 1956 Dec 1;104(6):803–815. doi: 10.1084/jem.104.6.803. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cooper M. J., Anders M. W., Mirkin B. L. Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine. Drug Metab Dispos. 1973 Sep-Oct;1(5):659–662. [PubMed] [Google Scholar]
- English A. R. Activity of tetracyclines, nalidixic acids, and nitrofurantoin in two experimental models of Escherichia coli urinary tract disease in rats. Proc Soc Exp Biol Med. 1971 Apr;136(4):1094–1096. doi: 10.3181/00379727-136-35435. [DOI] [PubMed] [Google Scholar]
- English A. R., Retsema J. A., Ray V. A., Lynch J. E. Carbenicillin indanyl sodium, an orally active derivative of carbenicillin. Antimicrob Agents Chemother. 1972 Mar;1(3):185–191. doi: 10.1128/aac.1.3.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wick W. E., Preston D. A., White W. A., Gordee R. S. Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973 Oct;4(4):415–420. doi: 10.1128/aac.4.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]