Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cancer J. 2015 Mar-Apr;21(2):88–96. doi: 10.1097/PPO.0000000000000102

Figure 4. Ductal Carcinoma in situ (DCIS).

Figure 4

Section of late stage comedo-type DCIS with central necrosis stained immunohistochemically with antibody against the glucose transporter, GLUT-1. Notable is the strong staining of peri-luminal cells which are expected to be hypoxic (see figure 3). GLUT-1 is a client of the hypoxia inducible factor, HIF-1α, and can be a biomarker for high rates of glycolysis.