Table 8.
Numerical distribution and statistical significance of VEGF-D/VEGFR-2 and VEGFR-2/pVEGFR-2Tyr1214 correlations in the vasculature of CC tissue
| VEGFR-2 | VEGF-D | p-value | VEGFR-2Tyr1214 | p-value | ||
|---|---|---|---|---|---|---|
| +/− | + | - | (r) | + | - | (r) |
| Ca zone 1 | 25 | 3 | 0.0001 | 41 | 5 | 0.0001 |
| 23 | 32 | (0.454) | 18 | 16 | (0.406) | |
| Ca zone 2 | 44 | 1 | 0.014 | 72 | 3 | 0.0001 |
| 32 | 7 | (0.267) | 3 | 4 | (0.531) | |
| Ca zone 3 | 39 | 8 | 0.025 | 57 | 1 | 0.001 |
| 21 | 14 | (0.256) | 17 | 5 | (0.356) | |
| SV zone 1 | 18 | 6 | 0.013 | 40 | 4 | 0.0001 |
| 17 | 20 | (0.313) | 12 | 14 | (0.494) | |
| SV zone 2 | 57 | 6 | 0.034 | 65 | 1 | 0.0001 |
| 11 | 5 | (0.236) | 6 | 4 | (0.524) | |
| SV zone 3 | 37 | 23 | NS | 40 | 1 | NS |
| 6 | 7 | 25 | 4 | |||
Positive vascular expression of VEGFR-2 is positively correlated with positive vascular VEGF-D expression and positive vascular VEGFR-2Tyr1214 expression in capillaries and small vessels in zone 1 and 2 and capillaries in zone 3. r = Spearman rank correlation coefficient. p < 0.05 was taken as statistically significant. NS, not significant. Ca = capillaries; SV = small vessels