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. 2015 May 13;11:27. doi: 10.1186/s12990-015-0018-1

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© Guedon et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Alleviation of VZV-induced hypersensitive nocifensive behaviors by administration of TNFα soluble receptor (sTNFR) expressed from an HSV vector. All animals (n = 4) were infected with VZV at day-0. At 21 days post VZV infection (denoted by arrowheads), animals were inoculated with either sTNFR vector (TNFasR) or control vector (T0ZHG). Animals were monitored for hypersensitivity to (top panel) mechanical (gram weight) and (bottom panel) thermal sensitivity (ratio of ipsilateral/contralateral paw withdrawal latencies) and the data is plotted as Mean + SEM. Each time-point was compared by two-tailed T-test (* = p < 0.05). Mean area under the curve was calculated for the region represented by brackets for each animal and compared by two-tailed T-test (* = p < 0.05, ** = p < 0.01) with the Mean ± SEM plotted.