Table 1.
Summary of characteristics of vital vectors used for pain analgesia and morphine tolerance/dependence
| AD | AAV | LV | HSV | |
|---|---|---|---|---|
| Wild-type | DS-DNA | SS-DNA | SS-RNA | DS-DNA |
| Genome size | 36 kb | 4.7 kb | 9.2 kb | 152 kb |
| Capacity of gene insert | ~7.5 kb | ~4.5 kb | ~8 kb | ~40 kb |
| Persistence of gene expression | days-weeks | months-years | months-years | days-years |
| Inoculation | IT | IT | IT, nerve | SC paw, PAG, bladder wall |
| Gene product | IL-10 | IL-10 | TNF shRNA, IL-10 | IL-4, IL-10, TNFSR |
| Pain models | NP | IP | NP | NP, IP |
| M-T/M-W | M-T | M-T, M-W |
DS-DNA, double strain DNA; SS-DNA, single strain DNA; SS-RNA, single strain RNA; IT, intrathecal; SC, subcutaneous injection; NP, neuropathic pain; IP, inflammatory pain; M-T, morphine tolerance; M-W, morphine withdrawal.