Table 3.
Associations between copeptin and continuous variables according to sex
| Variable | Women (n=529) | Men (n=481) | ||
|---|---|---|---|---|
| Correlation | P Value | Correlation | P Value | |
| Age (yr) | 0.12 | 0.01 | 0.07 | 0.13 |
| BMI (kg of body wt/m2) | 0.24 | <0.001 | 0.10 | 0.02 |
| Height (cm) | −0.13 | 0.002 | −0.19 | <0.001 |
| Systolic BP (mmHg) | 0.16 | <0.001 | 0.07 | 0.14 |
| Diastolic BP (mmHg) | 0.10 | 0.02 | −0.02 | 0.66 |
| eGFR (ml/min per 1.73 m2) | −0.12 | 0.01 | −0.12 | 0.01 |
| Plasma sodium (mmol/L) | 0.01 | 0.79 | 0.08 | 0.08 |
| Estimated plasma osmolarity (mOsm/L) | 0.02 | 0.73 | 0.08 | 0.09 |
| Plasma triglycerides (mmol/L) | 0.03 | 0.53 | −0.01 | 0.88 |
| 24-h urine flow rate (ml/min) | −0.38 | <0.001 | −0.41 | <0.001 |
| 24-h urine sodium excretion (mmol) | 0.001 | 0.98 | −0.02 | 0.62 |
| 24-h urine osmolality (mOsm/kg H2O) | 0.37 | <0.001 | 0.44 | <0.001 |
| 24-h urine creatinine excretion (mg/kg of body wt) | −0.16 | <0.001 | −0.02 | 0.67 |
| 24-h urine albumin excretion (mg) | 0.04 | 0.38 | 0.13 | 0.004 |
| 24-h osmolar excretion (mOsm) | −0.03 | 0.54 | −0.01 | 0.81 |
| Kidney length (mm) | −0.06 | 0.20 | −0.12 | 0.01 |
Data are Pearson’s correlation coefficients and corresponding P values. Copeptin, triglycerides, urine flow rate, 24-hour urine osmolality, and albumin excretion were log-transformed. Urine sodium and creatinine excretion were square-root transformed. Plasma osmolarity was calculated as 2×(Na+K). The 24-hour osmolar excretion was calculated as urine osmolality×24-hour urine volume.